Even though considerable research has gone into characterising and understanding the impact of sport injury on the mental health of athletes, relatively little is known about the potential influence of mental health and well-being on the likelihood and severity of injury. Starting with a major systematic review, the initial aim of the Podium Institute research is to understand the bi-directional association between mental health and wellbeing, and sports-related injury, in young people aged 10-24 years who play sport. With a particular focus on female and young athletes, which have been under-served by research to date, the aim is to uncover potential mechanisms and risk factors underpinning the relationship between mental health, well-being and sport injury in order to enable the development of improved prevention and management strategies.