Across all major UK sports, there is presently a paucity of data relating measures of forces, accelerations, contacts and vital signs acquired during exposure to injury, to clinically accepted neuroimaging and biochemical descriptors of the injury both shortly after it occurs and several months following recovery. A key focus of The Podium Institute is to address this gap in knowledge through the establishment of multi-modal studies across several major UK sports. These studies involve the characterisation of prospective cohorts of female, male and youth athletes across the community and professional sport at baseline, around the time of injury and with short-, medium- and long-term follow-up. Both wearables and computer vision techniques applied to video footage are extensively deployed to fully characterise the conditions surrounding potential injury, whilst an extensive in-hospital and mobile infrastructure is being put in place to enable both structural and functional imaging and neuroimaging with a few hours of suspected injury. Salivar, blood and other biomarkers are also being continuously collected to enable the identification and validation of potentially scalable biochemical and micro-RNA markers of injury. These multi-modal datasets are fed directly into personalised computational models of injury intended to help uncover its etiology, as well as to inform the development of a validated digital athlete model that can enable accelerated testing and validation of preventative strategies.