Football is the second most popular sport in the UK, with over 2 million adults and 1.5m children playing it at least twice per month. Our two key focus areas are understanding the short- and long-term effects of head impacts occurring either between ball and player or amongst players, and developing an improved understanding of the biomechanical causes and potential prevention of knee injuries. Ongoing multi-modal studies are enabling functional MRI scanning of teenage and adult athletes shortly after head impacts, in order to understand and characterize their functional as well as structural implications. Computer vision techniques and wearable sensors are also being utilised to inform advanced modelling of brain and knee biomechanics.